The use of cellular matrix in symptomatic knee osteoarthritis

The use of cellular matrix in symptomatic knee osteoarthritis

The knee osteoarthritis is a chronic, essentially incurable condition which affects people of different age and both genders. It has a slow, progressive course and may cause pain and limit range of motion. Various conservative and surgical treatments exist, with variable therapeutic outcomes.

Injection-based therapy including Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) gained a lot of popularity considering efficacy and high safety profile. These injections were usually applied separately. Earlier clinical studies were mainly focused on their individual effects. Cellular matrix represents the mixture of PRP and HA, injected directly into the joint.

In the pilot, single arm study, the group of researchers from Dubai Physiotherapy and Rehabilitation Center, Alexandria University, and Al Garhoud Private Hospital/FIFA Medical Center of Excellence tested safety and efficacy of cellular matrix in the treatment of patients with mild to moderate knee osteoarthritis. Besides injections, all patients received standardized physical therapy.

Preliminary results showed that the combination of PRP and HA (cellular matrix) is safe and efficient therapeutic model which can be applied together with physiotherapy.

This study is published in BJBMS.


Abbassy AA, Trebinjac S, Kotb N. The use of cellular matrix in symptomatic knee osteoarthritis. Bosn J of Basic Med Sci. 2020

Editor: Edna Skopljak, MD

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