An example of biomaterial implementation for reconstruction of cranial bone defects. After cranial surgery, artificial flaps made of methylmetacrylate are being used for covering of bone defects. Such artificial flap (on the left) was made according to the original and will replace the damaged original bone flap (right).
Author Summaries

Biomaterials and host versus graft response: A short review

January 1, 2017 0

Biomaterials and biotechnology are increasing becoming an important area in modern medicine. The main aim in this area is the development of materials, which are biocompatible to normal tissue. Tissue-implant interactions with molecular, biological and […]

Tissue specific processing of proglucagon. In the pancreatic α-cell, proglucagon is processed by PC2 activity into GRPP, glucagon, major proglucagon fragment (MPGF). In the L-cells, proglucagon is processed by PC1/3 into GLP-1 (7-36NH2) GLP-2 and glicentin. By further PC1/3 activity, glicentin can then be further cleaved into glicentin related pancreatic polypeptide (GRPP) and oxyntomodulin. N-terminal elongated glucagon has also been reported and is termed intestinal glucagon or enteroglucagon. Black arrowheads refer to side-viewing proglucagon antibodies, red arrowheads refer to N-terminal glucagon/oxyntomodulin antibodies and blue arrowheads refer to C-terminal glucagon antibodies. Glucagon measurement should therefore be carried out using, preferably a sandwich ELISA employing N and C-terminal glucagon antibodies. Assay only using black, blue or red antibodies (as depicted here) may over or underestimate glucagon levels due to cross-reactivity with other proglucagon molecules such as glicentin, oxyntomodulin or enteroglucagon 1-61.
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Do glucagonomas always produce glucagon?

January 1, 2017 0

Pancreatic islet α-cell tumours that overexpress proglucagon are typically associated with the glucagonoma syndrome, a rare disease entity characterised by necrolytic migratory erythema, impaired glucose tolerance, thromboembolic complications and psychiatric disturbances. Paraneoplastic phenomena associated with […]