Cervical cancer is the fourth most common female malignant tumor in the world. In the study published in BJBMS, the authors sought to establish a mathematical model to predict the 3-, 5-, and 10- year overall survival (OS) and cancer-specific survival (CSS) of early-onset cervical cancer patients, which is helpful for individualized treatment preparation and life extension.
The study was performed on 10 079 patients diagnosed with early-onset cervical cancer between 2004 and 2015 divided into training and validation sets randomly. In this study, the clinical variables including race, histological type, grade, AJCC stage, T stage, SEER stage, tumor size (cm), chemotherapy and radiotherapy, were considered the independent risk factors affecting the prognosis of early-onset cervical cancer patients.
In their study, the authors have established and validated a prognostic a mathematical model provided an accurate prediction of 3-, 5-, and 10-year OS and CSS of early-onset cervical cancer patients which contributed clinicians to be useful for patients’ counseling and clinical trials. However, further research is needed, considering the differences in cervical cancer between Chinese and American patients. Furthermore, more patients and more clinical data on Chinese patients with cervical cancer are needed, because the sample size in this study is relatively small in order to be reliable.
Liu Q, Li W, Xie M, Yang M, Xu M, Yang L, Sheng B, Peng Y, Gao L. Development and validation of a SEER-based prognostic nomogram for cervical cancer patients below the age of 45 years. Bosn J of Basic Med Sci. 2020
Editor: Edna Skopljak, MD