The mouse prostate: a basic anatomical and histological guideline

Gross view of mouse male urogenital organs. (A) Anterior and (C) posterior aspects of the urogenital tract dissected from an adult male mouse, as seen under the dissecting microscope. Urethra (U), Seminal vesicles (SV); (B) and (D) show the same images with dashed and dotted lines delineating the ventral (VP), lateral (LP), anterior (AP), and dorsal (DP) prostate lobes; (E) Anterolateral view (left side) of the prostate lobes relative to the bladder, seminal vesicles, and urethra (Modified from: Sugimura, Y., et al. [15]). Scale bar, 1 cm.
Gross view of mouse male urogenital organs. (A) Anterior and (C) posterior aspects of the urogenital tract dissected from an adult male mouse, as seen under the dissecting microscope. Urethra (U), Seminal vesicles (SV); (B) and (D) show the same images with dashed and dotted lines delineating the ventral (VP), lateral (LP), anterior (AP), and dorsal (DP) prostate lobes; (E) Anterolateral view (left side) of the prostate lobes relative to the bladder, seminal vesicles, and urethra (Modified from: Sugimura, Y., et al. [15]). Scale bar, 1 cm.

Despite substantial similarities in embryological, cellular and molecular biology features, human and mouse prostates differ in organ morphology and tissue architecture. Thus, a clear understanding of the anatomy and histology of the mouse prostate is essential for the identification of urogenital phenotypes in genetically engineered mice, as well as for the study of the etiology, development, and treatment of human prostatic diseases for which mouse models are used. The purpose of this manuscript is to provide a brief guide for the dissection of the mouse prostate and the identification of its different lobes and histology, to both basic researchers and medical pathologists who are unfamiliar with mouse tissues.

Reference:

Daniel S. M. Oliveira, Sijana Dzinic, Alan I. Bonfil, Allen D. Saliganan, Shijie Sheng, R. Daniel Bonfil. The mouse prostate: a basic anatomical and histological guideline. Bosn J Basic Med Sci. 2016; 16(1): 8–13. doi:  10.17305/bjbms.2016.917

recommended articles

Be the first to comment

Leave a Reply