Biomaterials and host versus graft response: A short review

An example of biomaterial implementation for reconstruction of cranial bone defects. After cranial surgery, artificial flaps made of methylmetacrylate are being used for covering of bone defects. Such artificial flap (on the left) was made according to the original and will replace the damaged original bone flap (right).
An example of biomaterial implementation for reconstruction of cranial bone defects. After cranial surgery, artificial flaps made of methylmetacrylate are being used for covering of bone defects. Such artificial flap (on the left) was made according to the original and will replace the damaged original bone flap (right).

Biomaterials and biotechnology are increasing becoming an important area in modern medicine. The main aim in this area is the development of materials, which are biocompatible to normal tissue. Tissue-implant interactions with molecular, biological and cellular characteristics at the implant-tissue interface are important for the use and development of implants. Implantation may cause an inflammatory and immune response in tissue, foreign body reaction, systemic toxicity and imminent infection. Tissue-implant interactions determine the implant life-period. The aims of the study are to consider the biological response to implants. Biomaterials and host reactions to implants and their mechanisms are also briefly discussed.

Reference:

Tomaz Velnar, Gorazd Bunc, Robert Klobucar, Lidija Gradisnik. Biomaterials and host versus graft response: A short review. Bosn J Basic Med Sci. 2016 May; 16(2): 82–90. doi:  10.17305/bjbms.2016.525

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