Low-grade glioma (LGG) belongs to a large class of gliomas, tumors that occur in the brain and spinal cord, with great intrinsic heterogeneity. In recent years, in-depth studies of the tumor microenvironment have made a […]
Colorectal cancer is the 3rd most common cancer worldwide. Immunotherapy has been shown to be therapeutically effective in patients with colorectal cancer who have significant levels of microsatellite instability (regions of repeated DNA that change […]
Le et al. recently reported (Science 10.1126/science.aan6733 (2017); (ClinicalTrials.gov number, NCT01876511) on the success of immune checkpoint blockade with anti-PD-1 antibodies in the patients whose cancers exhibited microsatellite instability-high (MSI-H) status. The study included 12 […]
Targeted therapy based on the immune checkpoint inhibitors (Anti-PD1/PD-L1) has revolutionized cancer treatment and outcome of several solid and hematologic malignancies, including non-small cell lung carcinoma (NSCLC), metastatic renal cell carcinoma, metastatic malignant melanoma, advanced/metastatic […]
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