A fresh viewpoint on how autophagy affects knee osteoarthritis

Ningxia Medical University

The influence of autophagy, or cell degradation, on osteochondral units in bones, as well as other modes of cell death are poorly understood. Therefore, researchers from the Ningxia Medical University and Shandong Provincial Hospital Affiliated to Shandong First Medical University sought to explore the effect of autophagy on knee osteoarthritis from a completely new perspective.

After inducing knee osteoarthritis in the right knee joint of mice by surgery, and subsequently activating autophagy by injection of rapamycin, researchers determined the relationship between autophagy and pyroptosis, which is another type of cell death, as well as bone remodeling in knee osteoarthritis by assessing pathological staining and microcomputed tomography. Data from the study indicate that autophagy may delay the pathological progression of knee osteoarthritis by inhibiting chondrocyte pyroptosis and improving bone remodeling.

Therefore, based on the received data, the authors believe that activation of autophagy can be considered a safe and effective mean of delaying the pathological progression of knee osteoarthritis.





Reference: Yan J, Feng G, Yang Y, Ding D, Ma L, Zhao X, Chen X, Wang H, Chen Z, Jin Q. Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Bosn J of Basic Med Sci [Internet]. 2022Jul.23 [cited 2022Jul.24];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7677

Editor: Merima Bukva, MPharm

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