The influence of autophagy, or cell degradation, on osteochondral units in bones, as well as other modes of cell death are poorly understood. Therefore, researchers from the Ningxia Medical University and Shandong Provincial Hospital Affiliated to Shandong First Medical University sought to explore the effect of autophagy on knee osteoarthritis from a completely new perspective.
After inducing knee osteoarthritis in the right knee joint of mice by surgery, and subsequently activating autophagy by injection of rapamycin, researchers determined the relationship between autophagy and pyroptosis, which is another type of cell death, as well as bone remodeling in knee osteoarthritis by assessing pathological staining and microcomputed tomography. Data from the study indicate that autophagy may delay the pathological progression of knee osteoarthritis by inhibiting chondrocyte pyroptosis and improving bone remodeling.
Therefore, based on the received data, the authors believe that activation of autophagy can be considered a safe and effective mean of delaying the pathological progression of knee osteoarthritis.
自噬或細胞降解對骨骼中骨軟骨單位以及其他細胞死亡模式的影響尚不清楚。因此，寧夏醫科大學和山東第一醫科大學附屬山東省立醫院的研究人員試圖從全新的角度探索自噬對膝關節骨性關節炎的作用。
在通過手術誘導小鼠右膝關節發生膝骨關節炎，隨後通過注射雷帕黴素激活自噬後，研究人員通過評估確定自噬與細胞焦亡（另一種類型的細胞死亡）以及膝骨關節炎中的骨重塑之間的關係病理染色和微計算機斷層掃描。研究數據表明，自噬可能通過抑制軟骨細胞焦亡和改善骨重塑來延緩膝關節骨性關節炎的病理進展。
因此，基於收到的數據，作者認為激活自噬可以被認為是延緩膝關節骨性關節炎病理進展的一種安全有效的手段。
Reference: Yan J, Feng G, Yang Y, Ding D, Ma L, Zhao X, Chen X, Wang H, Chen Z, Jin Q. Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Bosn J of Basic Med Sci [Internet]. 2022Jul.23 [cited 2022Jul.24];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7677
Editor: Merima Bukva, MPharm
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