Background Decitabine is an anticancer medicine that acts by epigenetic regulation of DNA. It activates viral elements in the human genome called endogenous retroviruses which, in turn, induce the expression of interferon-β that is designed […]
New study links immune-related thyroid issues to improved outcomes in patients with advanced non-small cell lung cancer. Non-Small Cell Lung Cancer: An Ongoing Challenge Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung […]
Le et al. recently reported (Science 10.1126/science.aan6733 (2017); (ClinicalTrials.gov number, NCT01876511) on the success of immune checkpoint blockade with anti-PD-1 antibodies in the patients whose cancers exhibited microsatellite instability-high (MSI-H) status. The study included 12 […]
Targeted therapy based on the immune checkpoint inhibitors (Anti-PD1/PD-L1) has revolutionized cancer treatment and outcome of several solid and hematologic malignancies, including non-small cell lung carcinoma (NSCLC), metastatic renal cell carcinoma, metastatic malignant melanoma, advanced/metastatic […]
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