Recent studies point to significant role of endothelial dysfunction in the pathogenesis of type 2 diabetes mellitus and its complications. However, an investigation of an association between asymmetric dimethylarginine (ADMA), as a novel marker of endothelial dysfunction, and glycaemic control in type 2 diabetes mellitus patients has yield conflicting results. Hence, the aim of the present study was to assess whether there is a correlation between ADMA and glycated haemoglobin, as a parameter of glycaemic control, in type 2 diabetes mellitus patients.
Furthermore, possible association between ADMA and lipid status in type 2 diabetes mellitus patients was also investigated within the present study. Results have shown increased values of ADMA in type 2 diabetes mellitus patients compared to healthy controls. Significant, positive, correlation between serum ADMA concentration and glycated haemoglobin levels was observed, while correlation between serum ADMA concentration and lipid status in type 2 diabetes mellitus patients was not established. Obtained findings suggest an interplay between endothelial dysfunction and glycaemic control in type 2 diabetes mellitus.
Possible explanation for observed association between endothelial dysfunction and glycaemic control may be oxidative stress that is increased in conditions of hyperglycaemia and it also promotes endothelial dysfunction. Bearing in mind that the present study failed to determine correlation between ADMA and lipid status, which might be due to small study sample, further investigation of possible association between ADMA and lipid profile in type 2 diabetes mellitus patients is required.
Bosnian/Croatian/Serbian language summary
Skorašnje studije ukazuju na značajnu ulogu endotelne disfunkcije u patogenezi diabetes mellitusa tip 2. Međutim, ispitivanja povezanosti između asimetričnog dimetilarginina (ADMA), kao novog markera endotelne disfunkcije, i kontrole glikemije kod pacijenta sa diabetes mellitusom tip 2 dala su nepodudarne rezultate. Stoga je cilj provedene studije bio ispitati da li postoji korelacija između ADMA i glikoziliranog hemoglobina, kao parametra kontrole glikemije, kod pacijenata sa diabetes mellitusom tip 2.
Nadalje, moguća povezanost između ADMA i lipidnog statusa kod pacijenata sa diabetes mellitusom tip 2 je također ispitivana u provedenoj studiji. Rezultati su pokazali povećane vrijednosti ADMA kod pacijenata sa diabetes mellitusom tip 2 u odnosu na kontrolne ispitanike. Značajna, pozitivna, korelacija je utvrđena između ADMA i glikoziliranog hemoglobina, dok korelacija između ADMA i lipidnog statusa kod pacijenata sa diabetes mellitusom tip 2 nije utvrđena. Dobijeni rezultati sugeriraju postojanje međusobne veze između endotelne disfunkcije i kontrole glikemije kod diabetes mellitusa tip 2.
Moguće objašnjenje dobijenih rezultata mogao bi biti oksidativni stres koji je povećan u uslovima hiperglikemije, a koji također potiče endotelnu disfunkciju. Imajući u vidu da provedena studija nije dokazala postojanje korelacije između ADMA i lipidnog statusa, što je moguća posljedica malog broja ispitanika uključenih u studiju, potrebna su daljna istraživanja povezanosti ADMA i profila lipida kod pacijenata sa diabetes mellitusom tip 2.
Reference
Začiragić Asija, Huskić Jasminko, Mulabegović Nedžad, Avdagić Nesina, Valjevac Amina, Hasić Sabaheta and Jadrić Radivoj. An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus. Bosn J Basic Med Sci. 2014 Feb;14(1):21-4. doi: 10.17305/bjbms.2014.2291
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